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The ninth episode of the series "Human 2040", entitled "I take care of myself", shows what solutions may soon support us in taking care of our health. How can technology improve our physical fitness? Will genetic diseases in the future be diagnosed and treated even before birth? And how might a pill we swallow allow us to control our body's condition? In the latest part of the "Man 2040" series, analysts from Polityka Insight discuss such issues as personalized medical therapy or the development of bionics. In the podcast on trends in taking care of oneself, the guest of Andrzej Bobiński, managing director of Polityka Insight, is Daria Abramowicz - a sports psychologist who has been working for many years with athletes, coaches, sports and business organisations, as well as parents of athletes of different ages, both in individual and team sports.



A CHINESE PROVINCE TESTS THE HUMAN 2.0 PROGRAM

The authorities of the Chinese Province of Hubei have announced a pilot program providing for the removal of restrictions on the modification of human embryo genetic material. A study group of 1,000 couples will not only be able to stop the inheritance of diseases, but also decide on selected external and internal characteristics of their children, such as height and eye color, but also intellectual and physical predispositions. The test will not allow the creation of human embryo hybrids with elements of genome of other species.

The controversial liberalization is a part of the ‘research section’ of the next National Prodemographic Program (NPP) announced by the Communist Party of China (CPC). The aim of the legislation is to stop demographic decline and aging of the population. The turnaround in the family policy of the CCP took place in 2015 when it was decided to move away from the ‘one child policy’ and couples were allowed to have two children, and then three children in 2021. Despite efforts by the authorities, Chinese citizens are not deciding to start families because of the need to change their lifestyles and the high costs of raising children. Although ethically questionable, the possibility of ‘modifying’ future offspring, together with the ‘from the cradle to adulthood’ financial support program, is intended to change this attitude.

Modifying human embryo genes to eliminate inoperable diseases (e.g. Huntington disease) has been common practice for several years. In many countries, however, the controversy over defining and shifting the boundaries of the permitted scope of change continues. These issues are regulated differently, but so far, no country has chosen to legalise the adaptation of the characteristics of the foetus to the wishes of parents. Such a practice was the domain of a thriving underground world of illegal clinics, where far-reaching gene modifications were common practice, albeit exclusively reserved for the richest. 

This is not the only shocking solution provided for in the NPP. In the event of insufficient improvement in the fertility rate by natural means, the Chinese government envisages, within five years, a pilot ‘embryo generation’ program in artificial wombs using genetic material owned by government research agencies. This evolving technology, which previously replaced incubators, now enables premature babies to survive for up to several days. Soon it is expected to permit foetal development from as early as artificial insemination in a test tube. 

‘HERE’S TO YOU’ PHARMACIES CLOSE THEIR LAST OUTLET

The outlet in Bielawa (part of the Wrocław and Świdnica megalopolis area) will remain open until the end of the year. The decision is a natural consequence of changes in the purchasing habits of Poles and the multifaceted revolution of the healthcare system, which has been taking place for years. The owner of the largest pharmacy network in Poland has not yet decided to close its traditional online shop, although automatic purchases made by e-physicians, i.e. algorithms using information provided by sensors located on and in the patient, account for 80% of orders.

In the last 15 years, sales in brick-and-mortar pharmacies, like stores in other market segments, have continued to decline and have stopped at 5-10%. However, in the case of the medicine market, there is no factor that has given a second life to some of the stores and shopping centers – the consumer does not need to try, see and physically interact with the product. Clothing stores have turned into ‘showrooms’ and traditional pharmacies have lost their meaning. In recent years, the facilities were mainly acting as pick-up stores where patients received medicines previously ordered. With improved logistics solutions responding to the so-called last-mile problem and adequate conditions for the transport and storage of medications (standalone drones or refrigerated vehicles), this aspect has also lost its meaning.

The fate of traditional pharmacies was also determined by the development of medicine and medical technologies, which have accelerated over recent years. Medicines available on the shelf with one specific dose and form (e.g. pills) have lost their raison d’etre. With the data collected and analyzed on an ongoing basis by algorithms and medical applications, it is possible to develop personalized medicaments, with a composition and structure that best respond to the biological needs or shortages of the particular organism. The whole process, from diagnosis, through ordering and delivery, until the medication is taken by the patient, is usually carried out without human involvement.

The phasing-out of pharmacies is also complementary to the ongoing changes in health protection. Nanotechnologies and miniaturization of medical devices have led to an increasing number of treatments and medical services in homes. Hospitals receive only the most difficult cases where non-standard treatment requires direct supervision or the involvement of a physician – a human. Others, in the privacy of their homes, use medicines and health analysis devices, which are ordered by virtual health assistants. Smart pills swallowed by patients provide live information and data from the human body: from gas concentrations and poten-tially hazardous substances to microcamera images to better diagnose malfunctions of the heart, stomach or other organs. Nanorobots, in turn, are micro-devices that support and pinpoint precise operations both outside (e.g. retina) and inside the body, but also perform needle biopsies. This type of treatment is not only more effective but also significantly reduces the period of convalescence of patients and the risk of post-treatment complications.

The abandonment of brick-and-mortar pharmacies is a decision that, although commercially justified, will have negative effects on some parts of society. People in rural areas and small towns will suffer the most. Older people usually living there already (because of digital exclusion) do not have access to the highest level of healthcare, and sometimes even to basic medical services. For them, the brick-and-mortar pharmacy was the last place where they could purchase necessary medicines and consult about their ailments ‘live’ with a doctor or pharmacist.

ATHLETES WITH BIONIC MODIFICATIONS WILL COMPETE IN THE NEW DELHI 2044 OLYMPIC GAMES

The International Olympic Committee has decided to allow athletes using, among other things, bionic prostheses to participate. During the event, which will take place in four years, the division between traditional and bionic athletes will be maintained. From the next Olympics onwards, everyone will compete together.

The IOC Decision is another step towards restoring the popularity of the Olympic Games. The actions taken so far, namely the introduction of disciplines geared closer towards younger audience (e.g. skateboarding and breakdance in the 20s) or the revolution in the 30s, allowing competition in several e-sport disciplines, have not produced the desired results. The Olympic Games, or more widely traditional sports events, have attracted a smaller audience for several years than the leagues and competitions organized by private operators, where bionic athletes compete. Their contests, available online in pay-per-view systems, are more spectacular and the contestants themselves achieve better results than traditional athletes.

The decision of the IOC will probably result in a complete departure from organizing the Paralympic Summer Games. The development of bionics has made it possible for people with disabilities and post-accident injuries to regain full function of their organs or to replace them with bionic prostheses directly controlled by the brain thanks to BCI (brain-computer interfaces). In the latter case, their results even outweighed those of traditional athletes. In the long term, athletes who rely exclusively on their own bodies will not be able to compete with bionic athletes.

The scope of permitted modifications of the organism remains a matter to be clarified by the IOC. Bionic prostheses will certainly be allowed, and exoskeletons, i.e. external devices covering the whole body or a selected part (e.g. legs), are not likely to raise much controversy. There may already be concerns, for safety reasons, about the modification of eyeballs (in shooting sports) and breathing organs (in swimming), which are technologies that are still in their infancy.

Undoubtedly, the challenge for the Olympic Committee will be to ensure the safety of competition. Most of the technologies that will be allowed from 2044 were originally developed for military purposes, enabling the creation of ‘‘super-soldiers,’ technologically supported and modified recruits used in wars, but also to help combat the negative effects of climate change. While the technologies themselves are not dangerous, due to the extreme performance of bionic athletes (e.g. speed, height or impact force), they carry a higher risk of injury or even death. According to critics of the IOC, the Olympic Games will be turned into a ‘death games’ (a reference to the dystopian series of novels written by Susan Collins at the beginning of the 21st century). The IOC, in allowing bionic athletes, also failed to address the ethical aspect of the problem of replacing organs with bionic ones by fully healthy people. This will certainly be done by most traditional athletes who want to be counted among the medal winners.

In recent years, the largest controversy in DNA modification therapies was related to CRISPR/Cas9. It makes it possible to locally remove a fragment of DNA thread and then repair it by the body itself or replace it with a new genome. The first pair of human twins with modified genes was due to be born in November 2018. The programme has stirred up a lot of controversy because, while it gives the chance to ‘edit’ undesirable genome sequences causing, among other things, hereditary diseases, it also allows for other, non-life-related modifications.

Read more:
Cyranoski, D. (2019) The CRISPR-baby scandal: what’s next for human gene-editing
Check Hayden, E. (2016) Should you edit your children’s genes?

Gene modification, but also genetic research, raises numerous issues that will pose challenges for national and supranational legislators. In response to, among others, the controversy over the CRISPR-Cas9 in July 2021, the World Health Organisation has published a report that includes recommendations on the modification of the human genome. The challenge will be not only the scope and procedures of changes in embryo DNA, but also the safety of data obtained by sequencing the human genome. This information is extremely sensitive – in unauthorised hands, it could pose a risk to the individual or individuals with specific genomic characteristics. One of the risks is the creation of targeted biological weapons that would target groups because of their genetic characteristics, such as ethnic origin. Meanwhile, according to a 2018 report by the Supreme Chamber of Control in Poland, not only is the information related to genetic research insufficiently protected, but there is also no legal framework in place.

Read more:
WTO (2021) Human genome editing: recommendations
Knapton, S. (2019) World must prepare for biological weapons that target ethnic groups based on genetics, says Cambridge University
NIK (2018) Zatrważające ustalenia NIK w sprawie badań genetycznych

Artificial womb development has been going on for a long time. So far, among mammals, researchers have been able to keep alive and grow mouse and sheep embryos for several weeks. In people, the youngest known premature baby, born in South Korea, who survived with the efforts of doctors and the support of incubators was 25 weeks and 5 days old. While this means that there is still a long way to go in the development of a child from embryo to ‘birth’ fully outside of the mother's body, researchers are not stopping in their efforts, and the topic is a matter for ethical considerations as well.

Read more:
Becker, R. (2017) An artificial womb successfully grew baby sheep — and humans could be next

This is the problem of delivering the shipment to the final retailer. When the product travels from the warehouse to the customer, the last-mile delivery is the most expensive and slowest part. At present, the last-mile problem is solved by building warehouses closer to end customers, parcel pick-up stations, delivery to pick-up stores and improved logistics. Autonomous vehicles can solve this problem in the future. We can imagine a courier parking at a central point of the street from where the drones delivering the product to all customers in the area fly away. 

Read more:
McKinsey (2019) The future of parcel delivery: Drones and disruption
McKinsey (2019) Debate: Will delivery UAVs scale by 2030?

The technology will enable the implementation of personalised medicine principles which are anticipatory, preventive, personalised and participatory (P4 medicine). Cheap and rapid sequencing of patient DNA will also open the way to personalised medicines.

Read more:
Ho, D. et al. (2021) Enabling Technologies for Personalized and Precision Medicine.
Lesko, L. J. (2007) Personalized Medicine: Elusive Dream or Imminent Reality?.
Bo Yang, Y. (2019) The role of genetics in medicine: A future of precision medicine

Nanotechnologies enable structures to be built at the level of single atoms and molecules. The European Commission defines nanomaterials as those which are of a size of 1-100 nm (nanometres). By comparison, the human hair diameter is approximately 80,000 nm.

Nanotechnological ‘smart pills’ are a very small electronic devices in the form of a pharmaceutical pill that allow for the detection, mapping and delivery of medicines. There are many prototype smart pills, but none are widely used yet. PillCam is a pill that contains a miniature camera. ‘Atmo Gas Capsule’ enables the level of oxygen, carbon dioxide and harmful substances in the body to be measured. MIT is working on a pill which will be attached to the wall of the small intestine where it will monitor health indicators and administer insulin according to the needs of the body. 

Read more:
Autonomy (2021) Going Public: Iceland's Journey to a Shorter Working Week.
Espinoza, M. (2019) The PillCam goes on a fantastic voyage to help diagnose GI bleeding
Haridy, R. (2018) Gas-sensing smart capsule expected as soon as 2022
Trafton, A. (2019) New capsule can orally deliver drugs that usually have to be injected

Bionics and human body modifications in general and its linkage to modern technologies are an area that will be rapidly developed in the coming years. Bionic prostheses controlled directly by brain-computer interface (BCI) technologies will be primarily used in medicine, making it possible for people with disabilities and post-accident injuries to recover the functioning of their own organs or replace them with an artificial equivalent without compromising their manual-cognitive abilities. Ethical concerns arise at a time when ‘artificial’ equivalents begin to outweigh the potential of the human body.

Read more:
Tracinski, R. (2017) The Future of Human Augmentation and Performance Enhancement

The Olympic Games have become increasingly less popular in recent years. The completed Games in Tokyo was watched on average by the fewest number of Americans since 1988. Declines have also been observed in other key markets in Europe and overseas. Although changes in audience size were partly due to time differences (Australia and Oceania saw increases in audiences compared to the Rio Games in 2016), the overall trend is clearly downward. Lower audiences mean less interest from sponsors, so it is to be expected that the IOC will endeavour to make the form of the Games more attractive, especially in the eyes of the youngest audiences.

Read more:
Coster, H. (2021) Analysis: Why TV audiences are tuning out the Tokyo Olympic Games, online: URL:

E-sport, or the competition of players in computer games, is a dynamically developing industry at the crossover between entertainment and traditional sport. Gaming competitions are becoming increasingly popular and their audiences, which follow the games not only online, but also during in-person tournaments, are growing. The number of viewers of e-sports competitions in the USA is estimated to increase from 21.1 million in 2019 to 31.4 million in 2023. Global e-sport revenues are expected to exceed USD 1 billion per year soon. The IOC already organised sideline e-sports competitions in five ‘disciplines’ during the Tokyo Games. Even more similar actions are planned for the next Games in Paris (2024). In the next few years, the addition of fully-fledged e-sports competitions to the Olympics programme seems inevitable.

Read more:
https://www.insiderintelligence.com/insights/esports-ecosystem-market-report/
https://strivesponsorship.com/wp-content/uploads/2020/03/Global-Esports-Market-Report-2020.pdf
https://www.washingtonpost.com/video-games/esports/2021/04/22/ioc-olympics-esports
https://steamuniverse.com/articles/2019/07/30/esports-joining-olympics-in-2024.aspx

Doubts and discussions about the advantages of artificial limbs over natural limbs have already taken place on the occasion of the historic appearance of Oscar Pistorius at the London Olympic Games in 2012. This South African runner competed with carbon prostheses on both legs. According to some public and academic opinions, this resulted in an unacceptable competitive advantage. As a result of these doubts, Paralympian Markus Rehm was not allowed to compete in the long jump at the Rio Games in 2016 (he also uses a carbon prosthesis). Although these athletes ultimately underperformed their fully healthy competitors, it seems only a matter of time before prosthetics are improved enough to outperform the human body.

Read more:
Greenemeier, L. (2016) Blade Runners: Do High-Tech Prostheses Give Runners an Unfair Advantage?
Berkes, H. (2012) Studying Oscar Pistorius: Does The 'Blade Runner' Have An Advantage?

Most of the bionic solutions, especially those aimed at exceeding the performance of the human body, and not only at reducing disablement, will be developed for military use. Science-fiction exo-skeletons or other solutions on the borderline between man and machine are already being tested, and within several years or so, they could be rolled out for use by modern armies. In recent years, the decision of the French Armed Forces, which allowed for the possibility of ‘bionic’ improvements to their soldiers, has been a widely discussed matter. There is no doubt that other armies will not retreat back from such a step in order to maintain a military advantage.

Read more:
Mizokami, K. (2020) Welp, France Just Signed Off on Cyborg Soldiers
Guy, J. (2020) French army gets ethical go-ahead for bionic soldiers